AICAR is a nucleotide molecule consisting of a ribose sugar, a phosphate group, and an adenine base. It is a precursor of adenosine monophosphate (AMP), a nucleotide that plays an important role in cellular energy metabolism. AICAR has been suggested to activate AMP-activated protein kinase (AMPK), an enzyme that regulates various metabolic processes. It has been studied for its potential applications, particularly in reducing reperfusion injury after tissue ischemia and mitigating metabolic disorders.
By activating AMPK, AICAR may increase glucose uptake in skeletal muscle, enhance insulin sensitivity, and improve glucose tolerance. AICAR has also been suggested by researchers to have anti-inflammatory potential and may improve exercise performance in animal studies.
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